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Catalog # HM6009

Lipid A, mAb 26-5


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The monoclonal antibody 26-5 recognizes lipid A. The lipid A domain of lipopolysaccharide (LPS) is a
unique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of
most gram-negative bacteria.
Lipid A is responsible for the endotoxic activities of LPS, and a heteropolysaccharide. The
heteropolysaccharide generally consists of an oligosaccharide termed the core region. This core region
is in some bacterial families composed of repeating oligosaccharide units, the so-called O chain. The
lipid A moiety of LPS is detected by the TLR4/MD2 receptor of the mammalian innate immune system.
Picomolar levels of lipid A induce macrophages to synthesize potent mediators of inflammation, such as
TNF-α and IL-1β. Furthermore, lipid A activates the production of costimulatory molecules required for
adaptive immunity and stimulates tissue factor production in mononuclear and endothelial cells. All
these events are desirable for clearing local infections.

Immuno assays

Product type
Monoclonal antibodies
100 µg, 20 µg
0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Mouse IgG2b
Storage and stability
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Infectious diseases
Protocol CoA-TDS
55 kb
Safety Data Sheet

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