Nectin-2, Mouse, mAb 502-57

Name: Nectin-2, Mouse, mAb 502-57
SKU: HM1052
Availability: InStock

€133.00 – €565.00

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Description
Application

Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of nectin-1, nectin-2 and nectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice. Monoclonal antibody 502-57 has been raised against the extracellular domain of mouse nectin-2. The antibody cross reacts with human nectin-2.

Application

Flow cytometry, Frozen sections, Immuno assays, Immuno precipitation, Western blot

Application Notes

The antibody can be used for immuno assays, Western blotting, immuno precipitation, flow cytometry and immunohistology on frozen sections.

Use

For flow cytometry, Western blotting and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. Fixation with PFA or acetone/methanol is recommended.

Specifications
Downloads

Product type

Monoclonal antibodies

Amount

100 µg, 20 µg

Formulation

0.2 ml (100 µg/ml) purified antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.

Isotype

Rat IgG2a

Species

Mouse

Cross reactivity

Human – Yes

Storage and stability

Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Precautions

For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.

Disease

Infectious diseases

Protocol