SI-CLP, Human, mAb 1C11
The monoclonal antibody 1C11 recognizes human stabilin-1 interacting chitinase-like protein (SI-CLP). SI-CLP is a 39 kD member of the family of Glyco_18-domain-containing proteins. These chitinase-like proteins are involved primarily in Th2-associated disorders and tumor progression. Chitinase-like proteins are soluble mediators of cell differentiation, proliferation, activation, migration, and adherence. Chitinase like protein SI-CLP is a stabilin-1 interacting partner. SI-CLP gene expression was up-regulated by IL-4 and dexamethasone on the mRNA and protein levels in primary human macrophages in parallel with the expression of stabilin-1. The major site of SI-CLP intracellular localization is in Lamp1-positive and secretion commited CD63+ secretory lysosomes. The endocytic/sorting receptor stabilin-1 is a highly specific intracellular sorting receptor for SI-CLP. SI-CLP directly binds to, and colocalizes with stabilin-1. The lysosomal localization of SI-CLP in stabilin-1-negative macrophages, however, indicates that stabilin-1 may not be the only receptor mediating trafficking of newly synthesized SI-CLP. In vivo, the monoclonal antibody 1C11 recognizes SI-CLP in the cellular fraction of bronchoalveolar lavage specimens obtained from patients with chronic inflammatory disorders of the respiratory tract and in peripheral-blood leukocytes (PBLs) from these patients as well as healthy donors.
Calculate your ELISA data easily
With the ELISA calculator you can easily calculate ELISA data. Assayfit Pro helps to perform curve fitting. The calculator generates advanced reports, fit graph, fit parameters and goodness of fit are shown.
We are glad to support you!
Our technical support team of qualified scientists is more than willing to assist.