TNF-alpha, Human, mAb 52B83
€133.00 – €368.00
The monoclonal antibody 52B83 specifically targets tumor necrosis factor alpha (TNF-alpha), a crucial protein in immune responses and inflammation. TNF-alpha, a 17 kDa homotrimeric protein, interacts with TNF-receptors I and II, initiating varied cellular signaling pathways.
Initially recognized for its anti-tumor effects, TNF-alpha destroys tumor cells both in vivo and in vitro, causing tumor necrosis and demonstrating cytolytic activity. Beyond its role in tumor biology, TNF-alpha stands at the center of many inflammatory and immunological processes. It responds to microbial products and other cytokines by triggering a broad cytokine response, illustrating its key position in inflammation.
TNF-alpha’s pro-inflammatory actions are particularly significant in autoimmune diseases like rheumatoid arthritis. Neutralizing TNF-alpha has proven beneficial, offering therapeutic potential in such conditions.
The 52B83 antibody’s interaction with TNF-alpha opens new avenues for treatment in autoimmune diseases, highlighting the importance of targeted therapies. This insight reinforces TNF-alpha’s vital role in immunology and inflammation research.
W: A reduced sample treatment and 15% SDS-Page was used. The band size observed is 17 kDa (Ref.4).
IHC-F: 6-μm tissue sections were fixed in acetone for 10 minutes (Ref. 4).
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