Home \ Antibodies \ C7, Human, mAb HB10G
Catalog # HM2425

C7, Human, mAb HB10G

Antibody HM2425clone HB10Grecognizes human complement C7 in its native form.Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces.

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125.00347.00

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Antibody HM2425 clone HB10G recognizes human complement C7 in its native form. Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces. However, its precise regulatory role in complement is poorly understood.

The main function of C7 is stabilizing the C5b6 complex after initiation of the terminal pathway. It is primarily synthesized extrahepatically at the site of inflammation by granulocytes and endothelial cells, thereby modulating lytic or sublytic membrane attack. Mutations in the C7 gene are associated with a rare disorder called C7 deficiency and affected individuals predisposed to angioedema, collagen vascular disease, or infections. Besides functioning as a single protein and its role in MAC formation, C7 might also form complexes with other proteins indicating potential regulatory functions.

Application
Immuno assays, Western blot

Product type
Monoclonal antibodies
Species
Mouse
Isotype
Mouse IgG1
Storage and stability
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least six months.
Country of Manufacture
NL
Disease
Autoimmunity, Cardiology and metabolism, Infectious diseases
Gene
Gene name: Complement C7, Enrtez Gene ID 730, Uniprot P10643
Formulation
0.2 µm filtered in PBS+0.02%NaN3+0.1%BSA
Immunogen
Truncated C7 protein covering the C-terminal end
Purification
Protein G
CoA-TDS Safety Data Sheet

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