Home \ Antibodies \ C7, Human, mAb HB2H
Catalog # HM2421

C7, Human, mAb HB2H

Antibody clone #HB2C2 recognizes a neo-epitope of complement C3dg. The antibody does not recognize C3 or (i)C3b

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Antibody HM2421 clone HB2H recognizes human complement C7 in its native form.Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces. However, its precise regulatory role in complement is poorly understood.

The main function of C7 is stabilizing the C5b6 complex after initiation of the terminal pathway. It is primarily synthesized extrahepatically at the site of inflammation by granulocytes and endothelial cells, thereby modulating lytic or sublytic membrane attack. Mutations in the C7 gene are associated with a rare disorder called C7 deficiency andaffected individuals predisposed to angioedema, collagen vascular disease, or infections.

Besides functioning as a single protein and its role in MAC formation, C7 might also form complexes with other proteins indicating potential regulatory functions.

Application
Immuno assays, Western blot

Application Notes
20 µg/ml

Product type
Monoclonal antibodies
Formulation
0.2ug filtered in PBS +0.02%NaN3+0.1%BSA
Species
Mouse
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Autoimmunity, Cardiology and metabolism, Infectious diseases
Cross reactivity
Mouse – Yes
Immunogen
Truncated C7 protein covering the C-terminal end
Gene
Gene name: Complement C7, Entrez Gene ID 730, Uniprot P10643
CoA-TDS HM2421 Safety Data Sheet

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