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Catalog # HM1153

TCC, Mouse, mAb 12C3

The monoclonal antibody 12C3 targets the C9 neoantigen within the Terminal Complement Complex (TCC), marking a critical juncture in complement system activation.

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The monoclonal antibody 12C3 targets the C9 neoantigen within the Mouse Terminal Complement Complex (TCC), marking a critical juncture in  complement system activation. The convergence of complement pathways leads to the formation of a C5 convertase, catalyzing the transition to the terminal pathway. Unlike earlier stages that rely on enzymatic cleavage, the terminal pathway is driven by conformational shifts upon sequential binding of components C6 through C9. This cascade results in the assembly of the TCC or Membrane Attack Complex
(MAC), instrumental in cell lysis and stimulating various cellular responses, including the release of inflammatory mediators. Unique neoantigens, not found in the individual native components, emerge in both membrane-bound and fluid-phase forms of the TCC. This indicates ongoing complement activity.

Clinically, the presence of TCC in mouse plasma or tissue serves as a biomarker for complement activation, with elevated
levels indicating heightened immune response. TCC can be a focal point for diagnostic and therapeutic that approach immune-mediated diseases.

Frozen sections, Immuno assays

Application Notes
IHC-F: Tested on mouse kidney tissue, since glomeruli in kidneys have a high complement disposition.

Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
100 µg, 20 µg
Quantities >500 µg will be send without preservative and carrier free. Quantities <500 µg will be send with preservative and carrier. exact formulation can be found on the datasheet.
Mouse IgG2b
Terminal complement complex, MAC complex, complement membrane attack complex, sC5b-9 complex
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.

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