The Lectin Pathway: Pattern Recognition
In the lectin pathway, mannose binding-lectin (MBL) together with MBL-associated serine proteases (MASP) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of microorganisms, MASP are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP-1, MASP-2 and MASP-3. The structure of these complexes and subsequent activation is quite similar to the C1-antibody complex from the classical pathway.
When The lectin pathway is activated this leads, via C2b and C4b, to the formation of the C3-convertase. From this point the cascade of protein activation is similar to the classical pathway, ultimately leading to the formation of the MAC complex in the membrane.
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