Home \ Antibodies \ CD59, Human, mAb MEM-43
Catalog # HM2120

CD59, Human, mAb MEM-43

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€125.00 – €481.00

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The antibody is the prototypic antibody for the CD59 determinant, a PI-linked glycoprotein of 18-25 kDa, which is broadly expressed on most types of cells. The antigen is the major complement-protecting molecule of human cells. It is expressed on all leukocytes, erythrocytes and most other cell types. Binding of this antibody inhibits the complement-protecting activity of CD59. CD59 is one of the complement regulatory membrane proteins that is missing in Paroxysmal Nocturnal Haemoglobinuria (PNH). Anti CD59 reagents may be useful in the differential diagnosis of PNH type II and PNH type I. Recently a role for CD59 in LPS signal transduction has been reported in keratinocytes. The antibody reacts with well defined epitope (W40, R-53) on CD59 molecule.

Application
Flow cytometry, Immuno precipitation, Paraffin sections, Western blot

Use
For flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For neutralization of biological activity dilutions have to be made according to the amounts endotoxin to be inactivated.

Product type
Monoclonal antibodies
Amount
100 µg, 20 µg
Formulation
Sterile 0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS and 0.1% bovine serum albumin with low endotoxin level.
Isotype
Mouse IgG2a
Species
Human
Storage and stability
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
Disease
Autoimmunity, Infectious diseases
Gene
Gene ID 966 uniprot P13987
Protocol
Protocol Western Blot
59 kb
Protocol SDS Page
57 kb
CoA-TDS
HM2120-20UG
91 kb
HM2120-100UG
91 kb
Safety Data Sheet
SDS - HM2120-100UG
52 kb
SDS - HM2120-20UG
52 kb

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