Home \ Antibodies \ Glyoxalase-I, Human, clone 17E6A12/G4
Catalog # HM2370

Glyoxalase-I, Human, clone 17E6A12/G4

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Monoclonal antibody 17E6A12/G4 recognizes human glyoxalase-I (GLO1). GLO1 is a major protein form the glyoxalase systems which is present in the cytosol of all cells. The function of this system is the metabolism of reactive dicarbonyl metabolites to less reactive products. GLO1 catalysis the isomerization of hemithioacetal derived from methylglyoxal and glutathione. GLO1 prevents the harmful accumulation of methylglyoxal. The GLO1 gene exist of 3 phenotypes. Embodying the homozygous and heterozygous expression of the protein. GLO1 consists of alpha helical regions and multiple beta strands. Protein and DNA modification by substrates of the glyoxalase system is linked to healthy aging, including diseases like diabetes and vascular dysfunction. This vascular impairment could lead to complications like retinopathy, nephropathy and bad wound healing. Overexpression of GLO1 in endothelial cells under hyperglycemic condition can revert the negative effects on angiogenesis. Glo1 is also considered to be a tumor suppressor protein and it is ubiquitously expressed in most tumor cells. Therefor inducers of GLO1 expression could be useful in cancer treatment.

Application
Western blot

Application Notes
W: A reduced or non-reduced sample treatment and SDS-Page can be used. The band size is ~25 kDa.

Product type
Monoclonal antibodies
Amount
100 µg, 20 µg
Formulation
0.2 ml (100 µg/ml) 0.2 µm filtered protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02 % sodium azide.
Immunogen
Recombinant Glyoxalase I
Isotype
Mouse IgG1
Species
Human
Alias
Lactoylglutathione lyase; Aldoketomutase; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS HM2300-HM2400
HM2370
53 kb
Safety Data Sheet

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