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TLR9, Mouse, antagonist (ODN2088)-0
Catalog # HC4074

TLR9, Mouse, antagonist (ODN2088)

The TLR9 antagonist HC4074 selectively inhibits mouse TLR9, pivotal in immune response modulation in diseases like arthritis and SLE.

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The TLR9 antagonist HC4074 targets mouse Toll-like receptor 9, inhibiting its activity to modulate immune responses. TLR9, distinctively located intracellularly, plays a pivotal role in recognizing pathogen DNA, differentiating between methylated vertebrate DNA and unmethylated pathogen DNA. This receptor’s activation within endosomal compartments triggers significant immune signaling pathways, engaging key proteins like MyD88. TLR9’s function in the immune system’s defense mechanism against various pathogens highlights its importance in research, particularly in conditions like arthritis and SLE, where specific synthetic ODNs like ODN2088 act as potent inhibitors.

Application
Functional studies

Use
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.

Product type
LPS and ligands
Amount
1 mg, 250 µg
Species
Mouse
Alias
Toll-like receptor 9, CD289<br> - Gene name: Tlr9
Formulation
Lyophilized product in MilliQ, containing 1 mg. Reconstitute the vial by pipetting 1 ml distilled or de-ionized water (Caution: vial is under vacuum).
Storage and stability
Lyophilized product should be stored at 4°C. Store stock solution in aliquots at –20°C. Repeated freeze and thaw cycles will cause loss of activity. Under recommended storage conditions, product is stable for one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Infectious diseases
CoA-TDS Safety Data Sheet

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