C4c, Human, clone 99-72-18
Antibody clone 99-72-18 recognizes human complement fragment C4c. C4c reflects the degree of complement activation via the classical and lectin pathway.Read more
Antibody clone 99-72-18 recognizes human complement fragment C4c. C4c reflects the degree of complement activation via the classical and lectin pathway. The complement system plays important roles in both innate and adaptive immune response and can produce an inflammatory and protective reaction to challenges from pathogens before an adaptive response can occur. It consists of a complex family of proteins and receptors which are found in the circulation, in tissues and other body-fluids. There are three pathways of complement activation. The classical pathway is initiated by Immune complexes; the lectin pathway by surface bound lectins; and the AP by all the surfaces that are not specifically protected against it. The C3 and C5 convertases are enzymatic complexes that initiate and amplify the activity of the complement pathways and ultimately generate the cytolytic MAC.
Initiation of the CP & LP leads to activation of C4 and C2. The arising anaphylotoxins activate the immune system. The larger fragments interact with cell surfaces, receptors, immune complexes or other complement proteins. This way among others the C3 convertase (C4b2b) is formed. The complement system is involved in a number of diseases like transplantation rejection, kidney diseases, AMD and inflammatory diseases. Therefor complement fragments serve as biomarkers for many of these diseases. C4 is a glycoprotein consisting of an alpha chain, beta chain and gamma chain. Activation yields C4a and C4b. C4b is inactivated by factor I in the presence of C4bp resulting in C4c and C4d. Thus soluble C4c is a measure of complement activation.
W: the monoclonal antibody is useful for Western blotting under non-reduced conditions. The expected band size for non-reduced samples is 146 kDa.
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