Home \ Antibodies \ CFHR1-2, Human, mAb JHD-7.10.1
Catalog # HM2301

CFHR1-2, Human, mAb JHD-7.10.1

120,00413,00

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The monoclonal antibody JHD-7.10.1 reacts with human complement factor H-related protein 1 and 2 (CFHR1/2). In humans the complement factor H protein family consists of complement factor H, the factor H-like protein 1 and five factor H-related proteins termed 1 to 5. All members of this group are expressed primarily in the liver and subsequently secreted into plasma. The secreted forms of these proteins are composed exclusively of repetitive protein domains termed short consensus repeats (SCR). The CFHR1 protein is composed of five SCR domains and circulates in plasma as two differentially glycosylated isoforms (37 kDa and 43 kDa). CFHR-2 is composed of four SCRs and is present in human plasma in a non-glycosylated form (24 kDa) and a glycosylated form of 29 kDa. So far the biological functions of both CFHR-1 and CFHR-2 proteins are poorly understood, however recent studies have shown that CFHR1 is a complement regulator that blocks C5 convertase activity as well as assembly and membrane insertion of the terminal components. Moreover, genetic variations in the CFHR1 gene are associated with several diseases such as atypical hemolytic uremic syndrome and age-related macular degeneration. Due to a high degree of amino acid sequence homology the monoclonal antibody is cross-reactive with both CFHR1 and 2. The antibody is suitable for immunoassay and Western blot applications.

Application
Immuno assays, Western blot

Use
For Immuno Assays and Western Blot, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Isotype
Mouse IgG1
Species
Human
Alias
Complement factor H related protein, CFHR
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Autoimmunity, Nephrology
CoA-TDS HM2200 - 2300
HM2301
48 kb
CoA-TDS HM2300-HM2400

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