Home \ Antibodies \ FHR-2, Human, mAb clone 2.12
Catalog # HM2433

FHR-2, Human, mAb clone 2.12

This monoclonal is unique, since it is not cross reactive with any of the seven proteins that belong to the Factor H (FH)-protein family.

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anti-FHR-2; clone 2.12 is a mouse monoclonal antibody recognizing human full length Complement Factor H-related protein 2 (FHR-2), a glycoprotein belonging to the family of complement regulatory proteins. FHR-2 has a molecular weight of approximately 29 kDa and is synthesized and secreted primarily by the liver but also by various immune cells, including monocytes, macrophages, and dendritic cells. Structurally, FHR-2 shares homology with Complement Factor H (CFH), which is a key regulatory protein within the complement system. Also FHR-2 is involved in the regulation of the complement cascade but its biological role is poorly understood somewhat controversial. Studies showed that FHR-2 inhibits the activity of the complement alternative pathway (AP) C3 convertase, thereby preventing MAC formation. On the other hand, it is described that a hybrid mutant protein consisting of FHR-5 domains and full length FHR-2 causes complement overactivation, which suggests that FHR-2 rather promotes AP activation. Dysregulation of FHR-2 is associated with diseases such as atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD). In these diseases, abnormal complement activation and deposition on host tissues can contribute to pathological processes. FHR-2’s involvement in the alternative pathway of the complement system positions it as a potential target for therapeutic interventions aimed at modulating complement-related diseases

Western blot

Application Notes
W: A reduced sample treatment and SDS-Page was used. The band sizes around ~25-30 kDa.

Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
100 µg, 20 µg
100 µg/ml 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Human Complement factor H-related protein 2
Mouse IgG1
Autoimmunity, Nephrology
Country of Manufacture
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS Safety Data Sheet Folders

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