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Catalog # HM2430

FHR-5, Human, mAb clone 5.1

This monoclonal is unique, since it is not cross reactive with any of the seven proteins that belong to the Factor H (FH)-protein family.

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Anti-FHR-5; clone 5.1 is a mouse monoclonal antibody recognizing human full length Complement Factor H-related protein 5 (FHR-5), a glycoprotein belonging to the family of complement regulatory proteins. It is synthesized and secreted primarily by the liver but also by immune cells such as monocytes, macrophages, and dendritic cells. FHR-5 has an approximate molecular weight of 65 kDa. Structurally, FHR-5 shares homology with Complement Factor H (CFH), a key regulator in the complement system. Also FHR-5 is part of the complement regulatory network, predominantly within the alternative pathway (AP) of the complement system. Many host ligands have been identified for FHR-5, such as C3b, heparin, CRP, PTX3 and components of the extracellular matrix. Various reports show that FHR-5 enhances the promotion of AP activation on cell surfaces. Surface-bound FHR-5 serves as a platform for the assembly of the AP C3 convertase. In addition, FHR-5 may compete with FH binding to certain surface ligands and inhibit FH regulatory activities. With regards to its role disease, (rare) genetic variants in the CFHR5 gene have been found in patients with atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD) and may contribute to the disease. In addition, circulating and glomerular FHR-5 associates with IgA nephropathy (IgAN) and familial C3 glomerulopathy (C3G). However, contradictory outcomes have been reported regarding FHR-5’s involvement in these diseases and other genes may also play a role, emphasizing the need for further research.

Western blot

Application Notes
W: A non-reduced and/or reduced sample treatment and SDS-Page was used. The band sizes around ~65-75 kDa.

Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
100 µg, 20 µg
100 µg/ml 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Human Complement factor H-related protein 5
Mouse IgG1
Autoimmunity, Nephrology
Country of Manufacture
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS Safety Data Sheet Folders

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