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Catalog # HM2430

FHR-5, Human, mAb clone 5.1

This monoclonal is unique, since it is not cross reactive with any of the seven proteins that belong to the Factor H (FH)-protein family.

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133.00414.00

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Anti-FHR-5 Antibody: Clone 5.1

Anti-FHR-5: clone 5.1, is a mouse monoclonal antibody that specifically recognizes human full-length Complement Factor H-related protein 5 (FHR-5). FHR-5 has a molecular weight of approximately 65 kDa and is synthesized and secreted primarily by the liver. However, it is also secreted and synthesized by immune cells such as monocytes, macrophages, and dendritic cells. Structurally, it shares homology with Complement Factor H (CFH), a key regulatory protein in the complement system.

Also FHR-5 is part of the complement regulatory network, predominantly within the alternative pathway (AP) of the complement system. It binds to numerous host ligands, including C3b, heparin, CRP, PTX3, and components of the extracellular matrix. Studies indicate that FHR-5 enhances AP activation on cell surfaces by serving as a platform for AP C3 convertase formation. It may also compete with CFH for surface ligand binding, reducing CFH’s regulatory activities.

Genetic variants in the CFHR5 gene are related to diseases such as atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD). In addition, circulating and glomerular FHR-5 associates with IgA nephropathy (IgAN) and familial C3 glomerulopathy (C3G). However, contradictory outcomes regarding its involvement highlight the need for further research to understand the need for further research.

Also check our newspage for all our available Factor H-related products: New ELISA’s for Factor H-related proteins

Application
Western blot

Application Notes
W: A non-reduced and/or reduced sample treatment and SDS-Page was used. The band sizes around ~65-75 kDa.

Use
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
Amount
100 µg, 20 µg
Formulation
100 µg/ml 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Immunogen
Human Complement factor H-related protein 5
Isotype
Mouse IgG1
Species
Human
Alias
CFHL5, CFHR5
Country of Manufacture
NL
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Disease
Autoimmunity, Nephrology, Neurological disorders
CoA-TDS Safety Data Sheet Folders

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