Home \ Antibodies \ FHR-3, Human, mAb clone 3.11
Catalog # HM2427

FHR-3, Human, mAb clone 3.11

This monoclonal is unique, since it is not cross reactive with any of the seven proteins that belong to the Factor H (FH)-protein family.


Read more


Please choose the quantity of items you wish to add to your cart…
Find distributor

Anti-FHR-3; clone 3.11 is a mouse monoclonal antibody recognizing human full length Complement Factor H-related protein 3 (FHR-3), a glycoprotein that belongs to the complement regulatory protein family. FHR-3 is synthesized and secreted primarily by the liver but also by immune cells such as monocytes, macrophages, and dendritic cells. It is present in plasma in various glycosylated forms ranging from 35 to 56 kDa. Structurally, FHR-3 shares homology with Complement Factor H (CFH), a pivotal regulator within the complement system. Also FHR-3 operates as part of the complement regulatory network, contributing to control of the complement cascade but its precise function is poorly characterized. FHR-3 predominantly exerts its regulatory influence within the alternative pathway (AP) of the complement system. Weak cofactor activity and an enhancement of the FH cofactor activity were reported, and also a marginal inhibitory effect was observed in hemolytic assays using FH depleted serum. However, these results need to be confirmed in independent studies. Disruptions in FHR-3 expression or function have been linked to specific diseases. For instance, imbalances in FHR-3 levels or activities have been associated with conditions like atypical hemolytic uremic syndrome (aHUS), age-related macular degeneration (AMD) and systemic lupus erythematosus (SLE). In these disorders, aberrant complement activation and deposition on self-tissues can contribute to pathological processes. FHR-3’s involvement in the alternative pathway positions it as a potential therapeutic target for interventions aimed at modulating complement-driven diseases. The participation of FHR-3 in the AP suggests its potential as a therapeutic target for interventions aimed at controlling diseases driven by complement dysregulation.

Western blot

Application Notes
W: A non-reduced and/or reduced sample treatment and SDS-Page was used. The band sizes around ~36-56 kDa.

Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
100 µg, 20 µg
100 µg/ml – 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Human Complement factor H-related protein 3
Mouse IgG1
Autoimmunity, Nephrology
Country of Manufacture
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS Safety Data Sheet Folders

You may also like…

You may be interested in…

Calculate your ELISA data easily

With the ELISA calculator you can easily calculate ELISA data. Assayfit Pro helps to perform curve fitting. The calculator generates advanced reports, fit graph, fit parameters and goodness of fit are shown.

Contact us