Home \ Antibodies \ LBP, Human, mAb 6G3
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Catalog # HM2043

LBP, Human, mAb 6G3

120,00462,00

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The monoclonal antibody 6G3 reacts highly specific with human natural and recombinant LBP. The antibody cross reacts with LBP of a large series of animal species including: sheep, pig, goat, rabbit, dog, rat, bovine and cynomologous monkey, it does not react with murine and horse LBP. The antibody binds to LBP-LPS complexes whereas it inhibits the interaction of this complex with CD14. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.

Application
Functional studies, Immuno assays, Immuno precipitation

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
0.2 ml (100 µg/ml) 0.2 µm filtered protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin.
Isotype
Mouse IgG1
Species
Human
Cross reactivity
Bovine – Yes, Canine – Yes, Goat – Yes, Monkey – Yes, Rabbit – Yes, Rat – Yes, Sheep – Yes, Swine – Yes
Storage and stability
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
Disease
Infectious diseases

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