Transgelin, Human, Assay

Transgelin, also known as SM22, is a cytoskeletal protein prominently expressed in smooth muscle cells, including those found in the gastrointestinal tract. Its primary function is associated with the regulation of actin dynamics. It contributes to the structural integrity and contractility of smooth muscle tissues.

In the context of gut health, the detection of transgelin can serve as a valuable biomarker for assessing gut damage and related pathological conditions. As a marker, it stands out in the detection of acute intestinal ischemia (AII). AII is a severe abdominal emergency with a high risk of morbidity and mortality. It results from mesenteric blood flow disruption associated with surgical procedures, hemorrhagic shock, trauma, and sepsis. This condition can cause severe damage to intestinal integrity, leading to the release of muscle cell proteins like transgelin. In oncology, transgelin proves valuable for diagnosing leiomyosarcoma.

The Transgelin ELISA kit provides a non-invasive method to assess the severity of gut damage caused by acute intestinal ischemia. It specifically detects disruptions in smooth muscle cells. When combined with I-FABP, a biomarker for epithelial gut damage, this kit offers an effective way to localize and evaluate intestinal injury. It eliminates the need for invasive procedures such as colonoscopy.