LAMP-2, Human, clone C8
Monoclonal antibody HM2372, clone C8 recognizes human lysosome-associated membrane protein-2 (LAMP-2; CD107b). LAMP-2 is a heavily glycosylated membrane protein expressed in lysosomes of 383 amino acids. It is a member of a family of membrane glycoproteins like MAP-1, LIMP2 and DC-LAMP. LAMP-2 is expressed in a broad panel of tissues like placenta, lung, liver and kidney. Glycosylation is dependent on cell type and activation status. LAMP-2 exists in three splice variants LAMP-2A, LAMP-2B and LAMP-2C. They differ in their sequence in the transmembrane and cytoplasmic domain that effects their function. LAMP-2 is important for control of lysosomal activity and traffic across the lysosomal membranes. Its ability to mediate fusion between auto phagosomes and lysosomes makes it important for the process of autophagy. The protein is also involved in cholesterol transport and cytoplasmic antigen MHCII presentation. Normally LAMP-2 is expressed at low levels on the cell surface. The degree of surface expression is dependent on the cell type and state of activation. Genetic deficiency of LAMP-2 causes Danon disease inducing cardiomyopathy and myopathy. Recent studies show also involvement in ANCA-vasculitis.
|Product type||Monoclonal antibodies|
|Formulation||0.2 ml (100 µg/ml) 0.2 µm filtered protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02 % sodium azide.|
|Application||Flow cytometry, Immuno assays|
|Alias||Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, LGP-96|
|Storage and stability||Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.|
|Precautions||For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.|
|Application:||Flow cytometry, Immuno assays|
|Application notes:||IA: Antibody clone C8 can be used as detection antibody.
FC: Extracellular staining with no fixation or permeabilization.