Home \ Antibodies \ Cathepsin G, Human, clone HB1F10
Catalog # HM2385

Cathepsin G, Human, clone HB1F10

Antibody clone HB1F10 recognizes human cathepsin-G (catG). CatG is a serine protease originating from human neutrophils.

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Antibody clone HB1F10 recognizes human cathepsin-G (catG). CatG is a serine protease originating from human neutrophils. Neutrophils contain four types of granules: azurophilic, specific, gelatinase and secretory granules. Their content is readily available and released in response to infection or inflammation. Azurophilic granules contain proteases, including neutrophil elastase, proteinase-3 and catG, that degrade extracellular matrix proteins. These proteins have a similar structure with a C-terminal α-helix and two β-barrels. Besides their extracellular role, intracellularly they cleave chemokines and cytokines in order to shape the inflammatory response. Independent of its enzymatic activity, catG is chemotactic for monocytes. CatG is predominantly present in neutrophils but has been identified in other mammalian cells like other myeloid cells. Recently, catG has also been detected in neutrophil traps (NETs) and urine exosomes. The main processes in which catG is involved include, pathogen clearance, regulation of inflammation, endothelial permeability and pathogenesis of some autoimmune diseases like SLE. If there is an imbalance with its inhibitors, like Serpinb1a and Serpinb6a, tissue damage and modulation of inflammation can be induced. CatG is crucial in resistance against infection with Staphylococcus aureus and contributes to protection against several fungal infections. Given the prominent role in inflammation, catG is involved in the pathophysiology of several serious human inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), Crohn’s disease, rheumatoid arthritis, cystic fibrosis and other conditions clinically manifested by excessive inflammatory reactions.

Application
Immuno assays

Application Notes
IA: Antibody HB1F10 can be used as capture and detection antibody.

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
0.2 ml (100 μg/ml) 0.2 μm filtered protein G purified antibody solution in PBS, containing 1.0% bovine serum albumin and 0.02% sodium azide.
Isotype
Mouse IgG2b
Species
Human
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS HM2300-HM2400
HM2385
54 kb

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