Home \ Antibodies \ Nectin-2, Human, clone TX31
Catalog # HM2393

Nectin-2, Human, clone TX31

Monoclonal antibody clone Tx31 recognizes human Nectin-2. Nectin-2 was initially discovered as a poliovirus receptor-related protein (PRR2).

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120,00413,00

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Monoclonal antibody clone Tx31 recognizes human Nectin-2. Nectin-2 was initially discovered as a poliovirus receptor-related protein (PRR2). Nectins are immunoglobulin-like transmembrane cell adhesion molecules expressed in various cell types. The nectin family consist of 4 members. Nectin-1/2/3 are expressed in cells like fibroblast, epithelial cells and neurons. Nectin-2 is also expressed in hematopoietic cells and spermatids. Nectins, which are ca2+-independent immunoglobulin like molecules, regulate cell-cell adhesions. They are involved in different type of disease like viral infection, autism, Alzheimer and cancer. Nectin-2 is believed to form homodimers or heterodimers in their function for cell adhesion. It forms an immune costimulatory function together with DNAM-1 thereby regulating both NK and CTL function.

Application
Flow cytometry, Functional studies, Western blot

Application Notes
- W: the antibody can be used for reduced and non-reduced samples. The expected band size is 48 kDa.
- FS: anti-CD112 mAb partially inhibited CD226-Fc binding to the CD112 transfectant. It is of note that anti-CD155 and anti-CD112 (TX-31) mAb partially, rather than completely, inhibited the cytotoxicity, probably because these mAb incompletely blocked interaction of CD226 with the ligands (Ref.1).

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
0.2 µm filtered in PBS+0.1%BSA
Immunogen
Recombinant protein
Isotype
Mouse IgG1
Species
Human
Alias
CD112, Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, Nectin cell adhesion molecule 2, Poliovirus receptor-related protein 2.
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Infectious diseases
CoA-TDS HM2300-HM2400

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