Home \ Antibodies \ S100A7, Human, mAb 2D9
Catalog # HM2329

S100A7, Human, mAb 2D9

120,00375,00

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Antibody 2D9 recognizes human S100A7 (Psoriasin). S100A7 is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-binding proteins. They are involved in a broad range of intra- and extracellular processes like regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a fundamental structural unit which is a highly integrated dimer, some as homodimer and others as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7 functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation. Furthermore, S100A7interacts with RAGE which drives an NF-B mediated proinflammatory response and recruitment of neutrophils.
S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Possibly, S100A7 adheres directly to and reduces survival of pathogens found on the epidermis and acts as a physical barrier. S100A7 also seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior

Application
Frozen sections, Functional studies, Immuno assays, Immuno fluorescence, Paraffin sections, Western blot

Application Notes
- W: A reduced sample treatment and SDS-Page was used. The band size is ~12 kDa.
- FS: Antibody clone 2D9 can be used as blocking antibody.
- IA: Antibody 2D9 can be used as detection antibody.
- No cross reactivity with S100A4, S100A8, S100A9, S100A11, S100P, S100B

Use
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
0.2 ml (100 μg/ml) 0.2 µm filtered and protein G purified in PBS+0.1%BSA
Immunogen
Full length human recombinant protein isolated from E.coli.
Isotype
Mouse IgG1
Species
Human
Cross reactivity
Mouse – No
Alias
Protein S100-A7, Psoriasin, S100 calcium-binding protein A7</br> - Gene name: S100A7, PSOR1, S100A7C
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Autoimmunity, Tumor immunology
CoA-TDS HM2300-HM2400
HM2329
121 kb

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