
Neurodegenerative diseases pose a significant challenge for individuals and society, and with treatments not always available, there is a critical need for new drugs. Although the precise pathophysiology of these diseases is often poorly understood, studies have shown that complement activation is a key component of the disease process. To further unravel the role of complement in these diseases, robust and well-validated assays to monitor complement activation are essential. Below you can find an overview of our assays that will help you further investigate the role of complement:
Commonly used complement products:
C1q – Classical Pathway Activation
C1q plays a vital role in initiating the classical complement pathway and is a key player in neuroinflammation and synapse pruning in neurodegenerative diseases.
- Human C1q ELISA Kit – Accurate quantification of C1q levels in serum, plasma, and bronchoalveolar lavage fluid (BALF) samples.
- C1q Monoclonal Antibodies – Ideal for multiple applications like IHC, immuno assays, Western blot, functional studies, immuno fluorescence.
- Mouse/Rat C1q Assay – Facilitates cross-species research into neurodegeneration and autoimmune disorders.
- Human C1s/C1-INH Complex Assay – C1s/C1-INH complex is a protective mechanism that limits complement-mediated damage in brain tissues. Assay also cross-reactive with mouse.
C3 & C5 – Central to All Complement Pathways
C3 is the core of the complement system, involved in the classical, alternative, and lectin pathways. Its activation fragments (C3a, C3b, iC3b, and C3d) are markers of ongoing inflammation and neurodegeneration.
- C3 ELISA Kit – Measures total C3 and C3 fragments to monitor complement activation.
- C3b and iC3b Antibodies and assays – Specific for activated fragments.
- C3 Fragment Assays – Ideal for tracking complement dysregulation.
- C5 ELISA Kit – Measures total C5, a key 190kDa protein in the complement system.
- C5a, Human ELISA Kit – for serum only, based on catching monoclonal antibody that recognizes a neo-epitope on C5a-desArg.
Factor H (FH) – Alternative Pathway Regulator
Factor H is crucial for regulating the alternative complement pathway and preventing excessive complement activation that can lead to tissue damage.
- Factor H and FHR ELISA Kits – Quantifies Factor H or FHR levels and function in biological samples. Are you the first to elucidate the intriguing role of FHR-proteins in neuroscience? Contact us for introduction possibilities.
- FH and FHR Monoclonal Antibodies – Designed for detecting Factor H and related proteins in multiple applications.
TCC (sC5b-9) – Terminal Pathway Marker
TCC (Terminal Complement Complex) in solution, or sC5b-9, is formed during the final step of complement activation and incorporation of the MAC-complex fails. TCC/MAC formation indicates full pathway activation and potential tissue damage.
- TCC (sC5b-9) ELISA Kit – Most wide-spread used assay in diagnostics and clinical studies for detecting TCC in serum, plasma, and CSF.
- TCC Antibodies – Suitable for multiple applications, like IHC and flow cytometry.
- Rat TCC Assay – Enables comparative research in preclinical models.
At Hycult Biotech, we offer advanced assays and antibodies designed to advance your neuroinflammation research across different species. Explore our full line of complement products and accelerate your discoveries today. We can assist you in your tailor-made complement needs.