Scientific Publications

  1. The Factor H family: four specific unmet challenges that need to be resolved

    This review was written in light of the perspective of principal investigators of the SciFiMed Consortium: a consortium aiming to create a comprehensive analytical system for the quantitative and functional assessment of the entire FH protein family. The FH-family consists of FH, FHL-1 and the five FHR proteins which are important regulators of the Read more...
  2. Complement and Thromboinflammation in SARS-CoV-2:

    When our adaptive immune system fails or responds too slow in pandemics, we need to be able to rely on our host defense and innate immune system. It has not only become more relevant for now, but also for future infections. As within the current SARS-CoV-2 / Covid-19 pandemic it is evident that the innate immune system has a pivotal role Read more...
  3. Blocking the Terminal Complement pathway to preserve kidney function following renal IRI?

    Summary of Bongoni, A et al; Complement-mediated Damage to the Glycocalyx Plays a Role in Renal Ischemia-reperfusion Injury in Mice. Transplantation Direct 2019.   The impact of complement activation was investigated on glycocalyx integrity and renal dysfunction in a mouse model of renal IRI (Ischemia-Reperfusion Injury). Animals were tested Read more...
  4. Tools for Complement research in rodents

    Summary of Kotima, J et al; Functional assessment of rat complement pathway activities and quantification of soluble C5b-9 in an experimental model of renal ischemia/reperfusion injury. J Immunol Methods 2014. Complement activation is being monitored more in both clinical settings as experimental models. To support the research in rat, mouse (and Read more...
  5. New biomarkers for NAFLD: PR3, NE and AAT

    Summary of Mirea, A et al; Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. Mol Med 2019.   Non-alcoholic fatty liver disease (NAFLD) is becoming a major health problem worldwide with a prevalence of approximately Read more...
  6. Alpha-1-antitrypsin as candidate for treating NAFLD

    Summary of Mirea, A et al; IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies. Trends in Molecular Medicine 2018; Volume 24, Issue 5, Pages 458-471 . For the full article, click here.  Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Eventhough underlying mechanisms are not Read more...
  7. Neutrophil elastase in ocular graft-versus-host disease

    Summary of Arafat, S. et al; Elevated neutrophil elastase in tears of ocular graft-versus-host disease patients. American Journal of Ophthamology Apr 2017. Click here for the full article. Graft-versus-host disease is a systemic complication and major cause of morbidity and mortality in patients that have undergone a transplantation procedure. It Read more...
  8. Antimicrobial peptides in obstructive uropathy

    Summary of Gupta, S. et al; Urinary antimicrobial peptides: potential novel biomarkers of obstructive uropathy. Journal of Pediatric Urology 2018. Click here for the full article. Antimicrobial peptides (AMPs) have historically been evaluated for their role in protecting against uropathogens. However, AMPs have not been evaluated for expression in Read more...
  9. Elastase and elafin as prognostic biomarkers for ARDS

    Summary of Wang, T. et al; Plasma neutrophil elastase and elafin as prognostic biomarker for acute respiratory distress syndrome: a multicenter survival and longitudinal prospective observation study. SHOCK Aug 2017. Click here for the full article. Acute respiratory distress syndrome (ARDS) is a complicated clinical syndrome with a high mortality Read more...
  10. Complement in first episode psychosis

    Summary of Kopczynska, M. et al; Complement system biomarkers in first episode psychosis. Schizophrenia Research, Dec 2017. Click here for the full article. There has been debate over the past few years about the criteria currently used to classify patients with psychiatric disorders. The lack of objective and quantitative diagnostic criteria means Read more...

Items 1-10 of 61

Page
Show per page