The Factor H family: four specific unmet challenges that need to be resolved

This review was written in light of the perspective of principal investigators of the SciFiMed Consortium: a consortium aiming to create a comprehensive analytical system for the quantitative and functional assessment of the entire FH protein family. The FH-family consists of FH, FHL-1 and the five FHR proteins which are important regulators of the complement system. Mutations and polymorphisms in the FH-family are involved in several diseases, indicating a potential crucial role of the FH-family in both health and disease.

What do we need to resolve?


A multidisciplinary approach is mandatory to overcome the challenges mentioned in the review, and is only possible through interdisciplinary collaboration between biologists, chemists, geneticists and physicians. The authors of this paper believe that we should essentially begin with quantifying the levels and activity of the different members of the FH-family in health and disease. Detection of the FH-protein family will enable the scientific and clinical community to advance our understanding of the role of the FH-protein family in infectious, eye, kidney and autoimmune diseases, and potentially help treat these disorders.


Also working on FH? Do not hesitate to share any comments or questions you might have! More information? Poppelaars F, Goicoechea de Jorge E, Jongerius I, Baeumner AJ, Steiner MS, Józsi M, Toonen EJM, Pauly D; SciFiMed consortium. Front Immunol. 2021 Mar 30;12:660194. doi: 10.3389/fimmu.2021.660194. eCollection 2021. PMID: 33868311