Alpha-V/Beta-3 Integrin, Human, mAb BV3

The monoclonal antibody BV3 recognizes human alpha-V/beta-3 integrin present on human cells.
Integrins are a superfamily of αβ heterodimeric cell-surface adhesion receptors found in many
species. They are expressed on a variety of cells and mediate numerous physiological processes,
including inflammation, migration, adhesion and proliferation. The β3 family consist of 2 members:
αIIbβ3 and αvβ3, which mediate cell-cell and cell-ECM interactions and are important for cellular
migration, regulation of gene expression, cell survival, adhesion and differentiation. All processes
which are involved in tissue development, angiogenesis and thrombosis. Each subunit consist of an
extracellular domain, a single transmembrane segment and a cytoplasmic tail. They connect to the
actin cytoskeleton via adaptor proteins that bind theircytoplasmic tails. Cell matrix adhesions also act
as signaling units by their capacity to organize the actin cytoskeleton and to accumulate various
signaling intermediates. Integrin αvβ3 was originally identified as the vitronectin receptor.
Nevertheless, other ligands include fibrinogen, fibronectin, laminin, thrombospondin, Von Willebrand
factor, tenascin, osteopontin and several forms of collagen. The interactions of integrin αvβ3 to those
ligands is mediated by the RGD (Arg-Gly-Asp) sequence motif present in these proteins. Deregulation
of β3 integrins is involved in e.g. autoimmune diseases, cardiovascular disorders, transplant rejection
and tumorigenesis. In contribution to the latter, integrin αvβ3 contribute by supporting growth of small
(tumor) blood vessels thereby potentiating the metastatic potential. Overexpression of integrin αvβ3
has been demonstrated in various tumors and activated endothelium.