FHR-2, Human, ELISA kit

Complement Factor H-Related Protein 2 (FHR-2) is a significant member of the complement regulatory protein family, with a molecular weight of around 29 kDa. Synthesized mainly in the liver, FHR-2 is also produced by immune cells like monocytes, macrophages, and dendritic cells. Sharing structural homology with Complement Factor H (CFH), FHR-2 plays a role in regulating the complement cascade, although its exact biological function remains somewhat elusive and subject to debate.
Research indicates that FHR-2 may inhibit the activity of the alternative pathway (AP) C3 convertase, which would theoretically prevent the formation of the membrane attack complex (MAC). Conversely, some studies suggest that FHR-2 might actually promote AP activation, highlighted by findings where a hybrid mutant protein comprising FHR-5 domains and full-length FHR-2 led to overactivation of the complement system.
FHR-2 has been linked to various diseases where abnormal complement activation is a contributing factor. Particularly, it is associated with atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD), where dysregulation in complement activation leads to detrimental tissue deposition. The involvement of FHR-2 in these pathologies, specifically in the alternative pathway, makes it a potential therapeutic target in managing diseases driven by complement dysregulation.
FHR-2 can be measured with our HK3004 assay, designed to precisely quantify this intriguing glycoprotein.