Home \ Antibodies \ Podoplanin, Human, clone LpMab17
Catalog # HM2375

Podoplanin, Human, clone LpMab17

120,00375,00

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Monoclonal antibody LpMab17 recognizes human Podoplanin (PDPN; agrrus). Podoplanin is a small type_I transmembrane sialoglycoprotein expressed on a broad range of cell types and involved in platelet aggregation and tumor metastasis. The 36 kDa protein was initially identified as a biomarker of lympatic endothelium, alveolar epithelium and glomerular podocytes. Expression has also been found in many tumors. However the functional role of PDPN is still poorly understood. Podoplanin consists of an extracellular domain, transmembrane domain and a cytoplasmic tail. In its extracellular domain it possesses a platelet aggregation stimulating (PLAG) domain. Podoplanin has got three PLAG domains of which PLAG3 is critical for binding with C-type lectin receptor-2 (CLEC-2). This PDPN specific receptor mediates platelet aggregation. This interaction is required to initiate and maintain separation of blood and lymphatic vessels and can be critical in process of cancer metastasis. This may lead to PDPN as possible therapeutic target. Antibody LpMab-17 recognizes a non-PLAg domain (Gly77-Asp82). Although PDPN is quite conserved between species, LpMab17 does not bind monkey PDPN.

Application
Flow cytometry, Immuno assays, Immuno fluorescence, Paraffin sections, Western blot

Application Notes
IA: Antibody LpMab17 can be used as detection antibody
. FC: HM2375 can be used both intra- and extracellular.
W: reduced and non-reduced conditions were used. The expected band sizes are ~40 kDa.

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
0.2 ml (100 µg/ml) 0.2 µm filtered protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02 % sodium azide.
Immunogen
LN229/hPDPN (Ref.1)
Isotype
Mouse IgG1
Species
Human
Alias
Aggrus, Glycoprotein 36, Gp36, PA2.26 antigen, T1-alpha, T1A
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS HM2300-HM2400
HM2375
67 kb

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