The Complement System 

The complement system is a crucial part of the immune system, consisting of over 30 proteins that work together to help identify and destroy foreign pathogens. There are three major pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway.

The complement system is a crucial part of the immune system, consisting of over 30 proteins that work together to help identify and destroy foreign pathogens. There are three major pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway.Welcome to our resource page, specially designed to help you with your research on the complement system. Our aim is to provide you with clear and helpful resources to make your research simpler and more successful.

Classical Pathway

The classical pathway is activated when antibodies bind to specific antigens on the surface of pathogens. This binding triggers a cascade of complement proteins to bind and activate one another, ultimately leading to the formation of the membrane attack complex (MAC) that punctures and destroys the pathogen’s cell membrane..

Lectin Pathway

The lectin pathway is activated when proteins called lectins bind to certain sugars on the surface of pathogens. This binding triggers a similar cascade of complement protein activation, leading to the formation of the MAC and pathogen destruction.

Alternative Pathway 

The alternative pathway is constantly active at low levels and can be triggered by the presence of certain molecules on the surface of pathogens or damaged host cells. This pathway also leads to the formation of the MAC and pathogen destruction.

All three complement pathways work together to provide a rapid and effective defense against invading pathogens. They also play a role in regulating the immune response and removing damaged host cells. Dysfunction of the complement system can lead to various diseases, including autoimmune disorders and infections.