Choosing the right C3 antibody: A researcher’s guide
Welcome to our comprehensive guide on choosing the perfect C3 antibody for your research. The complement system is a vital component of the immune system, and C3 antibodies play a pivotal role in various immunological studies. However, with numerous options available, it’s essential to select the right antibody to ensure the success of your research. This guide is designed to assist you in making an informed decision.
Our expert recommendations
Choosing the right C3 antibody is a critical step in your research journey. It can significantly impact the reliability and success of your experiments. By considering the factors mentioned in this guide and relying on our expertise, you can confidently select the perfect C3 antibody for your research.
Hycult Biotech specializes in providing high-quality C3 antibodies that have been extensively validated for various research applications. Our team of experts has made a list of antibodies to human C3 and C3 fragments as a C3 antibody guide to assist you in making the right choice for your specific needs.
| Product name | Reactivity | Clone | Applications | Cat.# | Literature | CoA-TDS |
|---|---|---|---|---|---|---|
| Activated C3 | neo-epitope expressed on the cleavage fragments of C3b, iC3b, and C3c | bH6 | F IA | HM2168 | Bioz | |
| Activated C3 | neo-epitope on C3b, iC3b and C3dg which is not present in native C3 | I3/15 | IA W | HM2257 | Scholar Google | |
| C3 (beta-chain) | recognize the human ß chain in complement C3. The ß chain (71 kDa) is, next to C3, present in the activation products C3b, iC3b and C3c | 169.5 | W | HM2377 | Scholar Google | |
| C3/C3a | recognizes the C-terminus of human complement protein C3a | 2898 | IA W | HM2075 | Bioz | |
| C3/C3a | reacts with an epitope on C3a. The antibody reacts both with intact C3 as with C3a | 474 | IA W | HM2073 | Bioz | |
| C3/C3b | recognizes an epitope located in the C-terminal 360 amino acids-on the alpha chain of C3, thereby recognizing C3b and full C3 | 755 | F IA P W | HM2072 | Bioz | |
| C3/C3b/iC3b (alpha-chain) | recognizes complement C3, C3b and iC3b (both in Western blot and immunoassay) and, to a lesser extent, also C3c and C3d (only immuno assays). The specific epitope is on the alpha chain domain MG8-C345C | 18.1 | IA W | HM2389 | Original publication | |
| C3/C3b/iC3b/C3c | recognize complement C3, C3b, iC3b and C3c. The recognition domain is determined to MG2-MG6; blocks alternative pathway C3-covertase formation | C3-16.4 | FS IA | HM2401 | Original publication | |
| C3a/C3a des Arg | recognizes the neo-epitope of human C3a/C3a-desArg that is formed upon cleavage of the complement protein C3 into C3a and C3b | 2991 | IA W | HM2074 | Bioz | |
| C3aR | reacts with the human receptor for C3a | 17 | F FC | HM2195 | Bioz | |
| C3b/iC3b | recognizes human complement C3b/iC3b and blocks activation of the alternative pathway (AP) | 3E7 | FC FS IF | HM2286 | Bioz | |
| C3b/iC3b | recognizes C3b/iC3b, it specifically binds human C3 as well as the breakdown products C3b and iC3b; inhibits the classical pathway | 5G9 | FS | HM2285 | Scholar Google | |
| C3b/iC3b/C3d | recognizes Complement Factor C3b/iC3b/C3d, it specifically binds human C3 as well as the breakdown products C3b, iC3b and C3dg | 1H8 | FC IP W | HM2287 | Bioz | |
| C3b/iC3b/C3c | recognize complement C3, C3b, iC3b and C3c. The recognition domain is determined to MG4/5; blocks C3 activation by AP C3-convertase | C3-42.3 | FS IA W | HM2394 | Original publication | |
| iC3b/C3dg/C3d | recognize complement iC3b, C3dg, and C3d. The recognition domain is determined to CUB-TED; blocks C3 activation by AP C3-convertase | C3-12.2 | IA W | HM2395 | Original publication | |
| C3c | recognizes the cleaved human C3 fragment C3c; recognizes a conformational epitope in C3c, C3b and iC3b | 4 | IP | HM2200 | Original publication | |
| C3c | recognizes a unique epitope exclusively present on human complement C3c | F1-4 | F IA IP W | HM2318 | Original antibody | |
| C3d | recognizes a neo-epitope of complement C3dg. The antibody does not recognize C3 or (i)C3b | HB2C2 | IA IP W | HM2422 | Unpublished data | |
| C3d | reacts with a linear determinant in C3d. This ‘D’ antigen is found on C3, C3b, iC3b, C3dg and C3d | 3 | IA IP | HM2198 | Bioz | |
| C3g | reacts with a neoantigen on iC3, iC3b, C3dg and C3g | 9 | IA IP | HM2199 | Original publications |
How we work
As an original manufacturer, Hycult Biotech understands the importance of quality and the need for well-characterized research products that work. The quality of bioreagents is difficult to assess beforehand and when it becomes an issue you will only find out when it is too late: After you have performed your experiments. Choosing Hycult Biotech products ensures your valuable time is spent on your research and not on the research tools.