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Choosing the right C3 antibody: A researcher’s guide

Welcome to our comprehensive guide on choosing the perfect C3 antibody for your research. The complement system is a vital component of the immune system, and C3 antibodies play a pivotal role in various immunological studies. However, with numerous options available, it’s essential to select the right antibody to ensure the success of your research. This guide is designed to assist you in making an informed decision.

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Choosing the right C3 antibody is a critical step in your research journey. It can significantly impact the reliability and success of your experiments. By considering the factors mentioned in this guide and relying on our expertise, you can confidently select the perfect C3 antibody for your research.
Hycult Biotech specializes in providing high-quality C3 antibodies that have been extensively validated for various research applications. Our team of experts has made a list of antibodies to human C3 and C3 fragments as a C3 antibody guide to assist you in making the right choice for your specific needs.

Product nameReactivityCloneApplicationsCat.#LiteratureCoA-TDS
Activated C3neo-epitope expressed on the cleavage fragments of C3b, iC3b, and C3cbH6F IAHM2168BiozPDF
Activated C3neo-epitope on C3b, iC3b and C3dg which is not present in native C3I3/15IA WHM2257Scholar GooglePDF
C3 (beta-chain)recognize the human ß chain in complement C3. The ß chain (71 kDa) is, next to C3, present in the activation products C3b, iC3b and C3c169.5WHM2377Scholar GooglePDF
C3/C3arecognizes the C-terminus of human complement protein C3a2898IA WHM2075BiozPDF
C3/C3areacts with an epitope on C3a. The antibody reacts both with intact C3 as with C3a474IA WHM2073BiozPDF
C3/C3brecognizes an epitope located in the C-terminal 360 amino acids-on the alpha chain of C3, thereby recognizing C3b and full C3755F IA P WHM2072BiozPDF
C3/C3b/iC3b (alpha-chain)recognizes complement C3, C3b and iC3b (both in Western blot and immunoassay) and, to a lesser extent, also C3c and C3d (only immuno assays). The specific epitope is on the alpha chain domain MG8-C345C18.1IA WHM2389Original publicationPDF
C3/C3b/iC3b/C3crecognize complement C3, C3b, iC3b and C3c. The recognition domain is determined to MG2-MG6; blocks alternative pathway C3-covertase formationC3-16.4FS IAHM2401Original publicationPDF
C3a/C3a des Argrecognizes the neo-epitope of human C3a/C3a-desArg that is formed upon cleavage of the complement protein C3 into C3a and C3b2991IA WHM2074BiozPDF
C3aRreacts with the human receptor for C3a17F FCHM2195BiozPDF
C3b/iC3brecognizes human complement C3b/iC3b and blocks activation of the alternative pathway (AP)3E7FC FS IFHM2286BiozPDF
C3b/iC3brecognizes C3b/iC3b, it specifically binds human C3 as well as the breakdown products C3b and iC3b; inhibits the classical pathway5G9FSHM2285Scholar GooglePDF
C3b/iC3b/C3drecognizes Complement Factor C3b/iC3b/C3d, it specifically binds human C3 as well as the breakdown products C3b, iC3b and C3dg1H8FC IP WHM2287BiozPDF
C3b/iC3b/C3crecognize complement C3, C3b, iC3b and C3c. The recognition domain is determined to MG4/5; blocks C3 activation by AP C3-convertaseC3-42.3FS IA WHM2394Original publicationPDF
iC3b/C3dg/C3drecognize complement iC3b, C3dg, and C3d. The recognition domain is determined to CUB-TED; blocks C3 activation by AP C3-convertaseC3-12.2IA WHM2395Original publicationPDF
C3crecognizes the cleaved human C3 fragment C3c; recognizes a conformational epitope in C3c, C3b and iC3b4IPHM2200Original publicationPDF
C3crecognizes a unique epitope exclusively present on human complement C3cF1-4F IA IP WHM2318Original antibodyPDF
C3drecognizes a neo-epitope of complement C3dg. The antibody does not recognize C3 or (i)C3bHB2C2IA IP WHM2422Unpublished dataPDF
C3dreacts with a linear determinant in C3d. This ‘D’ antigen is found on C3, C3b, iC3b, C3dg and C3d3IA IPHM2198BiozPDF
C3greacts with a neoantigen on iC3, iC3b, C3dg and C3g9IA IPHM2199Original publicationsPDF
Validated antibody applications: F: Frozen sections; FS: Functional studies; IF: Immunofluorescence; FC: Flow cytometry; IA: Immunoassay; IP: Immunoprecipitation; P: Paraffin sections; W: Western blot;

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As an original manufacturer, Hycult Biotech understands the importance of quality and the need for well-characterized research products that work. The quality of bioreagents is difficult to assess beforehand and when it becomes an issue you will only find out when it is too late: After you have performed your experiments. Choosing Hycult Biotech products ensures your valuable time is spent on your research and not on the research tools.

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