Home \ Choosing the right C3 antibody: A researcher’s guide

Choosing the right C3 antibody: A researcher’s guide

Welcome to our comprehensive guide on choosing the perfect C3 antibody for your research. The complement system is a essential part of the immune system and C3 antibodies are crucial in immunological studies. However, with numerous options available, it’s essential to select the right antibody to ensure the success of your research. This guide is designed to assist you in making an informed decision.

Our expert recommendations

Choosing the right C3 antibody is a critical step in your research journey. It can significantly impact the reliability and success of your experiments. Refer to this guide and our expertise to confidently choose the ideal C3 antibody for your research. Hycult Biotech offers top-quality C3 antibodies, thoroughly tested for diverse research uses. Our specialists have compiled a list of antibodies to human C3 and its fragments, creating a helpful guide to aid your selection.

Product nameReactivityCloneApplicationsCat.#LiteratureCoA-TDS
Activated C3Neo-epitope expressed on the cleavage fragments of C3b, iC3b, and C3c.bH6F IAHM2168BiozPDF
Activated C3Neo-epitope on C3b, iC3b and C3dg which is not present in native C3.I3/15IA WHM2257Scholar GooglePDF
C3 (beta-chain)Recognizes the human ß chain in complement C3. The ß chain (71 kDa) is, next to C3, present in the activation products C3b, iC3b and C3c..169.5WHM2377Scholar GooglePDF
C3/C3aRecognizes the C-terminus of human complement protein C3a.2898IA WHM2075BiozPDF
C3/C3aReacts with an epitope on C3a. The antibody reacts both with intact C3 as with C3a.474IA WHM2073BiozPDF
C3/C3bRecognizes an epitope located in the C-terminal 360 amino acids-on the alpha chain of C3, thereby recognizing C3b and full C3.755F IA P WHM2072BiozPDF
C3/C3b/iC3b (alpha-chain)Recognizes complement C3, C3b and iC3b (both in Western blot and immunoassay) and, to a lesser extent, also C3c and C3d (only immuno assays). The specific epitope is on the alpha chain domain MG8-C345C.18.1IA WHM2389Original publicationPDF
C3/C3b/iC3b/C3cRecognizes complement C3, C3b, iC3b and C3c. The recognition domain is determined to MG2-MG6; blocks alternative pathway C3-covertase formation.C3-16.4FS IAHM2401Original publicationPDF
C3a/C3a des ArgRecognizes the neo-epitope of human C3a/C3a-desArg that is formed upon cleavage of the complement protein C3 into C3a and C3b.2991IA WHM2074BiozPDF
C3aRReacts with the human receptor for C3a.17F FCHM2195BiozPDF
C3b/iC3bRecognizes human complement C3b/iC3b and blocks activation of the alternative pathway (AP).3E7FC FS IFHM2286BiozPDF
C3b/iC3bRecognizes C3b/iC3b, it specifically binds human C3 as well as the breakdown products C3b and iC3b; inhibits the classical pathway.5G9FSHM2285Scholar GooglePDF
C3b/iC3b/C3dRecognizes Complement Factor C3b/iC3b/C3d, it specifically binds human C3 as well as the breakdown products C3b, iC3b and C3dg.1H8FC IP WHM2287BiozPDF
C3b/iC3b/C3cRecognizes complement C3, C3b, iC3b and C3c. The recognition domain is determined to MG4/5; blocks C3 activation by AP C3-convertase.C3-42.3FS IA WHM2394Original publicationPDF
iC3b/C3dg/C3dRecognizes complement iC3b, C3dg, and C3d. The recognition domain is determined to CUB-TED; blocks C3 activation by AP C3-convertase.C3-12.2IA WHM2395Original publicationPDF
C3cRecognizes the cleaved human C3 fragment C3c; recognizes a conformational epitope in C3c, C3b and iC3b.4IPHM2200Original publicationPDF
C3cRecognizes a unique epitope exclusively present on human complement C3c.F1-4F IA IP WHM2318Original antibodyPDF
C3dRecognizes a neo-epitope of complement C3dg. The antibody does not recognize C3 or (i)C3b.HB2C2IA IP WHM2422Unpublished dataPDF
C3dReacts with a linear determinant in C3d. This ‘D’ antigen is found on C3, C3b, iC3b, C3dg and C3d.3IA IPHM2198BiozPDF
C3gReacts with a neo-antigen on iC3, iC3b, C3dg and C3g.9IA IPHM2199Original publicationsPDF
Validated antibody applications: F: Frozen sections; FS: Functional studies; IF: Immunofluorescence; FC: Flow cytometry; IA: Immunoassay; IP: Immunoprecipitation; P: Paraffin sections; W: Western blot;

Your key to C3 research

As a leading developer and manufacturer of C3 complement assays and antibodies, we take pride in our work. We proudly share our research tools and expertise with you. Importantly, our mission has always been to find answers to your questions and work towards improving health.

Explore our methods, applications, and C3 products

Contact us