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Your key to C3 detection

Welcome to our dedicated complement C3 page, your source for comprehensive information on C3 detection methods, applications, and products. Discover our range of solutions and stay on the forefront of C3 research.

Tools for C3 Research

Explore our specialized array of products to fulfill various research needs in the field of C3 detection.
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Choosing your C3 antibody

A comprehensive guide of antibodies to human C3, to meet your unique research requirements. Read more

Non-Human Primate Research 

Many of our complement assays are demonstrating promising cross-reactivity with NHP biomarkers. Read more

How to analyze complement

Learn which technique and pre-analytical sample to use in your research to avoid erroneous results. Read more

The Complement System

The complement system plays essential roles in both innate and adaptive immune responses, providing inflammatory and protective reactions against pathogens. Comprising a complex family of proteins and receptors found in circulation, tissues, and body fluids, it operates through three activation pathways: the classical pathway, initiated by immune complexes; the lectin pathway, activated by surface-bound lectins; and the alternative complement pathway, triggered on surfaces lacking specific protection.

The Alternative Pathway activation involves spontaneous C3 hydrolysis, binding to fB, forming C3(H2O)Bb convertase, which can be stabilized by properdin. Regulation comes from proteins like fH and fI. All pathways produce a C3 convertase, cleaving C3 into the major fragment C3b. These pathways converge with C3b initiating the second convertase, the C5 convertase, cleaving C5 into C5a and C5b, amplifying complement activity and forming the cytolytic MAC.

Significance of Complement C3

The complement system, an integral element of innate immunity, is heavily dependent on the C3 activation process. The third complement component, C3, is essential for the effective operation of the classical, alternative, and lectin pathways in the immune system. Activation of C3 plays a fundamental role in immune defense mechanisms, hence understanding and detection of C3 and its fragments is vital. In the realm of immunological research, the emphasis is increasingly on C3 detection, especially examining how antibodies interact with activated C3. This focus on C3 detection is pivotal for advancing our knowledge in immunology and developing new therapeutic strategies.

Developer and Manufacturer

As a leading developer and manufacturer of complement research tools, we take price in our work. Our mission has always been to find answers to your questions and work towards improving health. We have been fullfilling this mission since 1994. Our team posesses extensive expertise in the development and production of complement assays, antibodies, and proteins.

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Excellerate your Research

Our complete team consists of experienced professionals specializing in the complement system, with a rich history of publications to our name. We are passionate about advancing research in this area and are here to help you. With 30 years of experience and dedication to quality, we are well equipped to answer any questions you may have about our products or your research. We are happy to think along with you and offer tailor-made support.

Feel free to contact us directly by sending an email to or by completing the contact form. We are also open to giving workshops on location or offering help through online meetings.

Together we create greatness. Greatness in research, development and production due to more than 30 years of experience.

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