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Analyzing Complement Activity

Controlling the complement system is essential for studying immune responses and creating therapies for complement-related diseases. By using activators or inhibitors, researchers can either stimulate or suppress the system’s response. With tools like antibodies and ELISA kits, you can study and influence this system in detail.

Precision Tools for Targeted Therapeutics

In the expanding field of complement therapeutics, the demand for more precise quantitative methods is increasing. Since the approval of early complement-targeting drugs like C1-INH and Eculizumab (anti-C5), the number of clinical candidates in development has surged. Complement therapeutics, once focused on rare diseases, now extend to areas like autoimmunity, neurodegenerative disorders, cancer biology, and kidney transplantation. These treatments are no longer confined to the terminal complement pathway but also aim for targeted intervention within the classical and alternative pathways.

What do we offer?

We offer pathway-specific inhibitory compounds that can be customized to your needs, along with reagents that are easily accessible for experimental use, unlike restricted pharmaceutical compounds. Here is an overview of all a careful selection research tools to investigate complement inhibition or activation.

Classical pathway specific

Product ActivityCat.#
Anti-human C1s, mAb, clone 10/12Inhibitory antibodyHM2412
Anti-human C3b/iC3b, mAb, clone 5G9Inhibitory antibodyHM2285

Alternative pathway specific

ProductActivityCat.#
Anti-human C3b/iC3b, mAb 3E7Inhibitory antibodyHM2286
Anti-human Properdin, mAb 3A3E1Inhibitory antibodyHM2355

Terminal pathway specific

ProductActivityCat.#
Cobra Venom Factor, RecombinantActivatorHC4073
Anti-human C5/C5a (N-terminus), mAb, clone 561Inhibitory antibodyHM2076
Anti-human C5/C5a, mAb, clone 557Inhibitory antibodyHM2077
Anti-human C5, mAb, clone 10B6Inhibitory antibodyHM2414
Anti-mouse C5, mAb, clone BB5.1Inhibitory antibodyHM1073
Anti-rat C5, mAb, clone 4G2Inhibitory antibodyHM3044

Activity tests

Classical pathway specificSpecial feature(s)Cat.#
Human Classical Complement PathwayQuantitative, cross-reactive with non-human primatesHK3010
Mouse Classical Complement PathwayAlso available in combi kit with alternative and lectin pathway assayHIT420
Rat Classical Complement PathwayAlso available in combi kit with alternative and lectin pathway assayHIT410
Pig Classical Complement PathwayAlso available in combi kit with alternative and lectin pathway assayHIT430
Alternative pathway specific
Human Alternative Complement PathwayQuantitative, cross-reactive with non-human primatesHK3012
Mouse Alternative Complement PathwayAlso available in combi kit with classical and lectin pathway assayHIT422
Rat Alternative Complement PathwayAlso available in combi kit with classical and lectin pathway assayHIT412
Pig Alternative Complement PathwayAlso available in combi kit with classical and lectin pathway assayHIT432
Lectin Pathway specific
Human Lectin Complement PathwayUnder developmentInquire
Mouse Lectin Complement PathwayAlso available in combi kit with classical and alternative pathway assayHIT421
Rat  Lectin Complement PathwayAlso available in combi kit with classical and alternative pathway assayHIT411
Pig Lectin Complement PathwayAlso available in combi kit with classical and alternative pathway assayHIT431
TCC/C5b9 ELISA kits
Human TCC ELISAcross-reactive with pig and non-human primatesHK328
Mouse TCC ELISAUnder developmentInquire
Rat TCC ELISARat specificHK106

Facing Challenges?

Hycult Biotech is dedicated to creating advanced tools for studying treatments in complement-related diseases. If you do not find what you are looking for in our portfolio, it may already be in development or part of our scientific research projects. Share your biggest challenge with us, and we will work to solutions to meet your research needs.

Contact us and our team will reach out to discuss opportunities

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