TNF Receptor and TNF Antibodies
TNF receptor-targeted therapies are at the forefront of treatments for oncology and autoimmune diseases, including arthritis and inflammatory bowel disease (IBD). Modulating TNF receptors is crucial in these treatments, using the dual approach of antagonistic and agonistic antibodies to fine-tune immune responses. No matter which disease you delve into, the antibodies you choose serve as your most crucial tool. They help you achieve clearer insights and more conclusive results.
Agonistic and Antagonistic
Hycult Biotech has made a precise selection of antibodies that target TNF receptors and TNF-alpha. These antibodies play a dual role as essential biomarkers and functional active reagents, providing crucial insights into the complex inflammatory cascade of the TNF signalling pathway. Antagonistic antibodies to TNF receptors play a key role in reducing inflammation and autoimmune responses. On the flip side, agonistic antibodies enhance the efficacy of TNF receptors. As an example, the widely used MR2-1 antibody has shown to be a valuable tool for modulation of regulatory T Cell (Treg) activity. Find the right antibody for your research in the selection below:
| Antibody Name | Applications | Characteristics/notes | Article Number |
|---|---|---|---|
| TNF-RI | |||
| TNF-RI, Mouse, mAb HM104 | FC, F, IA, IP | HM1009 | |
| TNF-RI, Mouse, mAb 55R-170 | FC, FS | Antagnostic antibody useful for blocking of TNR-RI both in vitro and in vivo | HM1097 |
| TNF-RI, Mouse, pAb | FC, FS, IA, IP, WB | HP8002 | |
| TNF-RI, Human, mAb MR1-2 | FC, FS | HM2005 | |
| TNF-RI, Human, mAb H398 | FC, F, FS, IA, IP, WB | HM2020 | |
| TNF-RII | |||
| TNF-RII, Mouse, mAb HM102 | FC, FS | Agonistic | HM1011 |
| TNF-RII, Human, mAb MR2-1 | FC, FS | Agonistic antibody and receptor modulating antibody, useful for cell (culture) experiments | HM2007 |
| TNF-RII, Human, mAb 80M2 | FC, FS | Functions as an allosteric modulator, which stabilizes the ligand-receptor complex | HM2022 |
| TNF-RII, Mouse, pAb | FC, FS, IA, IP, WB | HP8003 | |
| TNF-RII, Human, pAb | FC, FS, IA, IP, WB | HP9003 | |
| TNF-alpha | |||
| TNF-alpha, Mouse, mAb V1q | FC, FS | Neutralizing antibody | HM1021 |
| TNF-alpha, Human, mAb 4H31 | FC, FS, F, IA, IP, WB | Useful for inhibition of the biological activity of TNF-alpha | HM2009 |
| TNF-alpha, Human, mAb 52B83 | FC, F, IA, WB | HM2010 | |
| TNF-alpha, Human, mAb T1 | FC, FS, IA, WB | Useful for inhibition of the biological activity of TNF-alpha | HM2024 |
| TNF-alpha, Human, mAb T3 | FC, FS, IA, IP, WB | Useful for inhibition of the biological activity of TNF-alpha | HM2026 |
| TNF-alpha, Human, mAb 5N | FS, IA | Useful for inhibition of the biological activity of TNF-alpha | HM2218 |
| TNF-alpha, Mouse, pAb | FC, F, FS, IA, P, WB | HP8001 | |
| TNF-alpha, Human, pAb | FC, FS, IA, WB | HP9001 |
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